The role of HIF in regulating systemic glucose and lipid metabolism

The liver and intestine undergo dynamic changes in oxygen levels following feeding and fasting response in mice. We have shown that these dynamic changes regulate systemic cholesterol and glucose levels, and if dysregulated lead to fatty liver and metabolic diseases. Current goals are to assess the molecular mechanisms by which oxygen levels regulate fatty acid, cholesterol, and glucose metabolism.

FASTED MICE

FASTED MICE

FED MICE

FED MICE