We study cellular and molecular control of oxygen signaling, its importance for human health and its role in disease
-Andrew Schwartz obtained his Ph.D in August 2019 is currently a postdoctoral fellow and Novartis, Boston, MA.
-Samantha Devenport obtained her Ph.D in Nov 2019 is currently Technical Patent specialist at Nelson Mullins Riley & Scarborough LLP Boston MA.
-Zou W, Shah YM. (2019). A PHD in immunosuppression: oxygen-sensing pathways regulate immunosuppressive Tregs. J Clin Invest. Jul19;130.
-Triner D, Shah YM. (2019). Hypoxic regulation of neutrophils in cacner. Int J Mol Sci. Aug 27;20(17).
-Devenport SN, Shah YM. (2019). Functions and implications of autophagy in colon cancer. Cells, In press.
-Das NK, Schwartz AJ, Barthel G, Inohara N, Liu Q, Sankar A, Hill D, Ma X, Lamberg O, Schnizlein MK, Arques JL, Spence JR, Nunez G, Patterson AD, Sun D, Young VB, Shah YM. Microbial metabolite signaling is required for systemic iron homeostasis. Cell Metab, In press.
-Cho CS, Kowalsky AH, Namkong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, Lee JH. Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury. Cell Discov, In press.
Billions of years of evolution in an oxygen environment has determined that oxygen occupies a central feature of our biology. Physiological hypoxia tends to be acute in nature and has cell specific responses thought to be important in maintaining cellular homeostasis. Whereas, pathological hypoxia is chronic and is hypothesized to be a driving force in tissue damage and cancer. The major goal of our research program is to determine the molecular mechanisms by which oxygen signaling regulate homeostasis, inflammation and cancer. Regulation of hypoxia-mediated genes is dependent on the nuclear transcription factor, hypoxia inducible factor (HIF). HIF signaling is critical in the adaptive response to low oxygen levels by activating genes involved in metabolism, angiogenesis, cell survival and iron metabolism. Using the latest in cell biology and mouse transgenic technology we have developed novel animal models and cell lines to study accurately the role of oxygen sensitive transcription factors in health and disease. These studies have revealed new pathways that have not previously been associated with hypoxia, and identified HIFs as major therapeutics targets in several diseases.